Florinda Ferreri

Dr. Ferreri’s research is centered around the study of cerebral activity in physiological condition, neurodegenerative and epileptic diseases through the application of electrophysiological techniques. Dr. Ferreri’s has a long-lasting expertise in clinical neurophysiology of the motor system and of cognitive functions, with a translational approach towards determining better rehabilitation approaches for stroke and dementia.

In the experimental neurophysiological laboratory of the Neuroscience Department Dr Ferreri focuses on multimodal combining of advanced electrophysiological (e.g., HdEEG, EMG, nTMS) and neuroimaging (e.g., MRI, fMRI, DTI) methods for the identification of novel biomarkers towards the early and non-invasive diagnosis of neurodegenerative diseases. In recent years, Prof. Ferreri’s commitment has been focused on the development of tailored Noninvasive Brain Stimulation (NiBS) approaches to promote brain physiological excitability, connectivity and plasticity to support the higher cerebral functions. Through basic neurobiologic insights from animal studies and modeling approaches, this research has the final goal of improving brain healthy aging and developing therapeutic approaches for patients with neurological conditions.

Ferreri F, Guerra A, Vollero L, Ponzo D, Määtta S, Könönen M, Vecchio F, Pasqualetti P, Miraglia F, Simonelli I, Corbetta M, Rossini PM. TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer's Disease: A Proof-of-Concept Six Years Prospective Study. Front Aging Neurosci. 2021 Nov 22;13:737281. doi: 10.3389/fnagi.2021.737281. eCollection 2021. IF 5.750

Rossini PM, Di Iorio R, Bentivoglio M, Bertini G, Ferreri F, Gerloff C, Ilmoniemi RJ, Miraglia F, Nitsche MA, Pestilli F, Rosanova M, Shirota Y, Tesoriero C, Ugawa Y, Vecchio F, Ziemann U, Hallett M. Methods for analysis of brain connectivity: An IFCN-sponsored review. Clin Neurophysiol. 2019 Oct;130(10):1833-1858. doi: 10.1016/j.clinph.2019.06.006. Epub 2019 Jul 2. Review.

Guerra A, Pogosyan A, Nowak M, Tan H, Ferreri F, Di Lazzaro V, Brown P. Phase Dependency of the Human Primary Motor Cortex and Cholinergic Inhibition Cancelation During Beta tACS. Cereb Cortex. 2016 Oct;26(10):3977-90. doi: 10.1093/cercor/bhw245. Epub 2016 Aug 13.

Ferreri F, Vecchio F, Vollero L, Guerra A, Petrichella S, Ponzo D, Määtta S, Mervaala E, Könönen M, Ursini F, Pasqualetti P, Iannello G, Rossini PM, Di Lazzaro V. Sensorimotor cortex excitability and connectivity in Alzheimer’s disease: A TMS-EEG Co-registration study. Hum Brain Mapp. 2016 Jun;37(6):2083-96. doi: 10.1002/hbm.23158. Epub 2016 Mar 4.

Rossini PM, Burke D, Chen R, Cohen LG, Daskalakis Z, Di Iorio R, Di Lazzaro V, Ferreri F, Fitzgerald PB, George MS, Hallett M, Lefaucheur JP, Langguth B, Matsumoto H, Miniussi C, Nitsche MA, Pascual-Leone A, Paulus W, Rossi S, Rothwell JC, Siebner HR, Ugawa Y, Walsh V, Ziemann U. Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee. Clin Neurophysiol. 2015 Feb 10. Review.

Ferreri F, Vecchio F, Ponzo D, Rossini PM. Time-varying coupling of EEG oscillations of primary motor cortex predicts excitability fluctuations as reflected by motor evoked potentials amplitude: an EEG-TMS study. Hum Brain Mapp. 2014 May;35(5):1969-80.

Ferreri F, Ponzo D, Hukkanen T, Mervaala E, Könönen M, Pasqualetti P, Vecchio F, Rossini PM, Määttä S. Human brain cortical correlates of Short-latency Afferent Inhibition (SAI): a combined EEG-TMS study. J Neurophysiol. 2012;108(1):314-23.

Ferreri F, Pasqualetti P, Määttä S, Ponzo D, Ferrarelli F, Tononi G, Mervaala E, Miniussi C and Rossini PM. Human brain connectivity during single and paired pulse transcranial magnetic stimulation. Neuroimage 2011;54(1):90-102.

Ferreri F. Curcio G. Patrizio P. De Gennaro L. Fini R. and Rossini PM. Mobile phone emission and human brain excitability. Ann Neurol. 2006 Aug;60(2):188-96.

Ferreri F, Pauri F, Pasqualetti P, Fini R, Dal Forno G, PM Rossini. Motor cortex excitability in Alzheimer Disease. Ann Neurol. 2003 Jan;53(1):102-8.

GR-2016-02361802. Prediction of conversion from Mild Cognitive Impairment to Alzheimer’s disease based on TMS-EEG biomarkers.