Edoardo Vincenzo Savarino

My main interest in the gastroenterology field include  the neurogastroenterology (motility and physiology of the gastrointestinal tract) and immune-mediated diseases (inflammatory bowel diseases and eosinophilic disorders of the gastro-intestinal tract), considering both the translational and clinical aspects. Moreover, in the last years, we have developed a strong interest on the role of microbiome in different conditions and aspects of the life, by collecting and funding a group of collaborators who work in synergy to explore the value of microbiome assessment in terms of pathogenesis, diagnosis and management of various disorders, including the neurological and inflammatory ones. We also started in Padua one of the first center for microbiota transplantation in Italy, which already treated patients with Clostrioides difficle infection, tranplanation and autism. I have published extensively (h-index 51, published papers n=435) on gastroesophageal reflux disease (GERD), esophageal motility disorders, Barrett’s Esophagus, functional GI disorders (functional dyspepsia, irritable bowel syndrome), eosinophilic esophagitis, microbiome and inflammatory bowel diseases.

Barberio B, Facchin S, Patuzzi I, Ford AC, Massimi D, Valle G, Sattin E, Simionati B, Bertazzo E, Zingone F, Savarino EV. A specific microbiota signature is associated to various degrees of ulcerative colitis as assessed by a machine learning approach. Gut Microbes. 2022 Jan-Dec;14(1):2028366. doi: 10.1080/19490976.2022.2028366.

Barberio B, Massimi D, Bonfante L, Facchin S, Calò L, Trevenzoli M, Savarino EV, Cattelan AM. Fecal microbiota transplantation for norovirus infection: a clinical and microbiological success. Therap Adv Gastroenterol. 2020 Aug 11;13:1756284820934589. doi: 10.1177/1756284820934589

Barberio B, Facchin S, Mele E, D'Incà R, Sturniolo GC, Farinati F, Zingone F, Quagliariello A, Ghisa M, Massimi D, Casadei C, Savarino EV. Faecal microbiota transplantation in Clostridioides difficile infection: real-life experience from an academic Italian hospital. Therap Adv Gastroenterol. 2020 Jul 29;13:1756284820934315. doi: 10.1177/1756284820934315

Facchin S, Vitulo N, Calgaro M, Buda A, Romualdi C, Pohl D, Perini B, Lorenzon G, Marinelli C, D'Incà R, Sturniolo GC, Savarino EV. Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease. Neurogastroenterol Motil. 2020 Oct;32(10):e13914. doi: 10.1111/nmo.13914. Epub 2020 May 31

Savarino E, Bhatia S, Roman S, Sifrim D, Tack J, Thompson SK, Gyawali CP. Achalasia. Nat Rev Dis Primers. 2022 May 5;8(1):28. doi: 10.1038/s41572-022-00356-8.

Raine T, Bonovas S, Burisch J, Kucharzik T, Adamina M, Annese V, Bachmann O, Bettenworth D, Chaparro M, Czuber-Dochan W, Eder P, Ellul P, Fidalgo C, Fiorino G, Gionchetti P, Gisbert JP, Gordon H, Hedin C, Holubar S, Iacucci M, Karmiris K, Katsanos K, Kopylov U, Lakatos PL, Lytras T, Lyutakov I, Noor N, Pellino G, Piovani D, Savarino E, Selvaggi F, Verstockt B, Spinelli A, Panis Y, Doherty G. ECCO Guidelines on Therapeutics in Ulcerative Colitis: Medical Treatment. J Crohns Colitis. 2022 Jan 28;16(1):2-17. doi: 10.1093/ecco-jcc/jjab178.

Torres J, Bonovas S, Doherty G, Kucharzik T, Gisbert JP, Raine T, Adamina M, Armuzzi A, Bachmann O, Bager P, Biancone L, Bokemeyer B, Bossuyt P, Burisch J, Collins P, El-Hussuna A, Ellul P, Frei-Lanter C, Furfaro F, Gingert C, Gionchetti P, Gomollon F, González-Lorenzo M, Gordon H, Hlavaty T, Juillerat P, Katsanos K, Kopylov U, Krustins E, Lytras T, Maaser C, Magro F, Marshall JK, Myrelid P, Pellino G, Rosa I, Sabino J, Savarino E, Spinelli A, Stassen L, Uzzan M, Vavricka S, Verstockt B, Warusavitarne J, Zmora O, Fiorino G. J Crohns Colitis. ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment. 2020 Jan 1;14(1):4-22. doi: 10.1093/ecco-jcc/jjz180.

D'Haens G, Kelly O, Battat R, Silverberg MS, Laharie D, Louis E, Savarino E, Bodini G, Yarur A, Boland BS, Afif W, Li XJ, Hale M, Ho J, Kondragunta V, Huang B, Kuy C, Okada L, Hester KD, Bray KR, Mimms L, Jain A, Singh S, Collins A, Valasek MA, Sandborn WJ, Vermeire S, Dulai PS. Development and Validation of a Test to Monitor Endoscopic Activity in Patients With Crohn's Disease Based on Serum Levels of Proteins. Gastroenterology. 2020 Feb;158(3):515-526.e10. doi: 10.1053/j.gastro.2019.10.034. Epub 2019 Nov 8

Sands BE, Peyrin-Biroulet L, Loftus EV Jr, Danese S, Colombel JF, Törüner M, Jonaitis L, Abhyankar B, Chen J, Rogers R, Lirio RA, Bornstein JD, Schreiber S; VARSITY Study Group. Vedolizumab versus Adalimumab for Moderate-to-Severe Ulcerative Colitis. N Engl J Med. 2019 Sep 26;381(13):1215-1226. doi: 10.1056/NEJMoa1905725

Danese S, Colombel JF, Lukas M, Gisbert JP, D'Haens G, Hayee B, Panaccione R, Kim HS, Reinisch W, Tyrrell H, Oh YS, Tole S, Chai A, Chamberlain-James K, Tang MT, Schreiber S; GARDENIA Study Group. Etrolizumab versus infliximab for the treatment of moderately to severely active ulcerative colitis (GARDENIA): a randomised, double-blind, double-dummy, phase 3 study. Lancet Gastroenterol Hepatol. 2022 Feb;7(2):118-127. doi: 10.1016/S2468-1253(21)00294-6. Epub 2021 Nov 17

a) 2008 - Title of The Research Project “Pathogenic Mechanisms And Common Therapeutic

Strategies In the Immune-Related Dermatopathies Associated To Chronic Enteropathies” Funded by Italian Ministry of Instruction, Research and University – PRIN 2008

b) 2009 - Title of The Research Project “Evaluation Of Small Bowel Distension After Ingestion of Oral Lactulose By Means Of Magnetic Resonance Imaging In Healthy Volunteers And A Group Of Patients With Irritable Bowel Syndrome” Funded by Italian Society of Gastroenterology (SIGE)

c) 2010 - Title of The Research Project “Relationship Between Gastro-oesophageal Reflux And Idiopathic Pulmonary Fibrosis – A Study Using Impedance-pH And High Resolution Computed Tomography” Funded by Italian Society of Gastroenterology (SIGE)

d) 2014 - Title of The Research Project “Esophageal High Resolution Manometry To Differentiate Eosinophilic Esophagitis And Proton Pump Inhibitors-Responsive Esophageal Eosinophilia” Funded by the Azienda Ospedaliera di Padova (AOU di Padova)

e) 2015 - Title of The Research Project “Oesophageal Intraluminal Baseline Impedance Levels In Patients With Systemic Sclerosis – Diagnostic Implications” Funded by the Azienda

Ospedaliera di Padova (AOU di Padova)

f) 2016 - Title of The Research Project “ Gut microbiota modulation and inflammation in inflammatory bowel disease and acute prostatitis / chronic pelvic pain ” Funded by the Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua

g) 2017 - Title of The Research Project “Impact of Chronicity on Disability and Quality of Life in Patients with Ulcerative Colitis on the National Territory - Longitudinal Observational Study” Funded by the Italian Group of Inflammatory Bowel Disease

h) 2018 - Title of The Research Project “ Esophageal Achalasia, Thyroid Diseases, Autoimmune Gastritis and Celiac Disease: Are They Related Autoimmune Diseases?” Funded by the Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua

i) 2018 - Title of The Research Project “Effectiveness of Tofacitinib On ExtraIntestinal Manifestations in Patients with Ulcerative Colitis” Funded by Pfizer trough a competitive Grants Programme (INflammation & ImmuNology COmpetitiVe GrAnt ProgRam for Research - INNOVARE)

l) 2019 - Title of The Research Project “The Role of Bacterial Proteases in Thrombosis and Amyloidosis (BPTA)” Funded by the CaRiPaRo Foundation

m) 2020 - Title of The Research Project “Interaction Between Esophageal Inflammatry Signaling Pathway, Mucosal Afferent Nerves, Gut Microbiome, and Mucosal Permeability in the Pathogenesis of Eosinophilic Esophagitis (EoEInOut)” Funded by the University of Padua (STARS Consolidator Grant of STARS@UNIPD2019)

n) 2021 – Title of the Research Project “ECCO Grant: Decoding the Neuroimmune Crosstalk in Inflammatory Bowel Disease” Funded by ECCO

o) 2021 – Title of the Research Project “Tofacitinib in Ulcerative Colitis: extra-intestinal manifestation IBD-related and safety” Funded by Pfizer (2021 I&I RE-CUP-IT - Competitive Grant Program)