Andrea Porzionato

The Prof. Andrea Porzionato, specialized in Legal Medicine and Ph.D. in Neuroscience, is mainly involved in research fields about neuroanatomy and neuropathology of the central and peripheral nervous systems, through integration of macroscopic, microscopic (immunohistochemistry/immunofluorescence), ultrastructural and morphometric approaches.

In the stabulary of the Institute of Human Anatomy he developed a series of experimental protocols in rodents about nerve injury, tissue engineering, bronchopneumodysplasia (BPD) (evaluation of therapies with stem cells and extracellular vesicles) and intestinal inflammatory diseases (DSS-related injuries, also with reference to the enteric nervous system).   

He is also involved in judicial autopsies with implications in terms of Medical Liability/Responsibility and forensic neuropathology.

The following projects are underway at our laboratory:
- topographical studies of brainstem nuclei;
- histopathologic analyses of hypoxic-ischaemic injuries in the central nervous system;
- COVID-related findings in the central and peripheral nervous systems;
- structure, physiology and plasticity of the carotid body;
- forensic clinical anatomy, with particular reference to neuropathology;
- development of neuroguides for nerve injuries (experimental models);
- evaluation of innovative therapeutic approaches for BPD (experimental models);
- evaluation of innovative therapeutic approaches for intestinal inflammatory pathologies (DSS-related bowel injuries).

Bioactivated Oxidized Polyvinyl Alcohol towards Next-Generation Nerve Conduits Development.
Stocco E, Barbon S, Lamanna A, De Rose E, Zamuner A, Sandrin D, Marsotto M, Auditore A, Messina GML, Licciardello A, Iucci G, Macchi V, De Caro R, Dettin M, Porzionato A.Polymers (Basel). 2021 Sep 30;13(19):3372. doi: 10.3390/polym13193372.

Experimental Evidence of A2A-D2 Receptor-Receptor Interactions in the Rat and Human Carotid Body.
Stocco E, Sfriso MM, Borile G, Contran M, Barbon S, Romanato F, Macchi V, Guidolin D, De Caro R, Porzionato A.
Front Physiol. 2021 Apr 15;12:645723. doi: 10.3389/fphys.2021.645723.

Small intestine neuromuscular dysfunction in a mouse model of dextran sulfate sodium-induced ileitis: Involvement of dopaminergic neurotransmission.
Cerantola S, Faggin S, Caputi V, Bosi A, Banfi D, Rambaldo A, Porzionato A, Di Liddo R, De Caro R, Savarino EV, Giaroni C, Giron MC.
Life Sci. 2022 Jul 15;301:120562. doi: 10.1016/j.lfs.2022.120562.

Case Report: The Carotid Body in COVID-19: Histopathological and Virological Analyses of an Autopsy Case Series.
Porzionato A, Emmi A, Contran M, Stocco E, Riccetti S, Sinigaglia A, Macchi V, Barzon L, De Caro R.
Front Immunol. 2021 Oct 26;12:736529. doi: 10.3389/fimmu.2021.736529.

Sympathetic activation: a potential link between comorbidities and COVID-19.
Porzionato A, Emmi A, Barbon S, Boscolo-Berto R, Stecco C, Stocco E, Macchi V, De Caro R.
FEBS J. 2020 Sep;287(17):3681-3688. doi: 10.1111/febs.15481.

The potential role of the carotid body in COVID-19.
Porzionato A, Emmi A, Stocco E, Barbon S, Boscolo-Berto R, Macchi V, De Caro R.
Am J Physiol Lung Cell Mol Physiol. 2020 Oct 1;319(4):L620-L626.

Impairment of human dopaminergic neurons at different developmental stages by perfluoro-octanoic acid (PFOA) and differential human brain areas accumulation of perfluoroalkyl chemicals.
Di Nisio A, Pannella M, Vogiatzis S, Sut S, Dall'Acqua S, Rocca MS, Antonini A, Porzionato A, De Caro R, Bortolozzi M, Toni L, Foresta C.
Environ Int. 2022 Jan;158:106982. doi: 10.1016/j.envint.2021.106982.

3D Reconstruction of the Morpho-Functional Topography of the Human Vagal Trigone.
Emmi A, Porzionato A, Contran M, De Rose E, Macchi V, De Caro R.
Front Neuroanat. 2021 Apr 16;15:663399. doi: 10.3389/fnana.2021.663399.

Anatomy and Connectivity of the Subthalamic Nucleus in Humans and Non-human Primates.
Emmi A, Antonini A, Macchi V, Porzionato A, De Caro R.
Front Neuroanat. 2020 Apr 22;14:13. doi: 10.3389/fnana.2020.00013.

Intravascular large B-cell lymphoma affecting multiple cranial nerves: A histopathological study.
Porzionato A, Pelletti G, Barzon L, Contran M, Emmi A, Arminio A, Macchi V, De Caro R.
Neuropathology. 2021 Oct;41(5):396-405. doi: 10.1111/neup.12767. Epub 2021 Sep 19.